Technical Description
The invention is a method for intracellular delivery using infrared LED light activated optoporation over self-aligned TiO2 nanotube arrays. The setup photothermally generates localized vapor nanobubbles that collapse to create temporary cell membrane pores, allowing external molecules to enter safely via passive diffusion.
Problems Addressed
- High Toxicity of Viral Vectors
- Severe Shear Stress in Sonoporation
- Low Chemical Transfection Efficiency
- Bulky, Vibration-Sensitive Machinery
- Contamination Risks in Electroporation
- Non-Uniform, Low-Throughput Transfection
Tech Features
- 2D Titanium Dioxide Nanotubular Arrays
- Biocompatible NIR Spectrum
- Passive Intracellular Diffusion Mechanism
- Lightweight Portable Form (< 500 g)
- Optoporation-Driven Molecule Delivery
- Vapor Nanobubble & Fluid Jet Activity
Target Audience
- Pharmaceutical
- Healthcare Industries
- Biotechnology & Gene Therapy
Tech ID: P26-2069 TRL 4 Patent Status: Granted Available For Exclusive and Non-exclusive License
