Technical Description
This invention uses N‑methyl‑2‑pyrrolidinone 5‑hydroperoxide (NMPOOH) with a base as a highly efficient, benign epoxidation reagent, especially for electron‑deficient olefins. It offers high yields, strong stereo/chemoselectivity, and broader substrate scope than many existing peroxide systems.
Problems Addressed
- Limited Epoxidation Selectivity
- Poor Diastereocontrol
- Explosive Peroxides
- Low Reagent Stability
- Complex Synthesis Routes
- Heteroatom Over‑oxidation
Tech Features
- NMPOOH/Base System
- Electron‑Poor Olefins
- High Dia Stereo Selectivity
- Strong Chemo Selectivity
- Mild, Benign Conditions
- Broad Substrate Scope
Target Audience
- Agrochemical Manufacturers
- Pharmaceutical Manufacturing
- Fine Chemicals Sector
- Contract Development Manufacturing
- Chiral Intermediates Industry
- Research & Development
Tech ID: P27-1847 TRL 4 Patent Status: Granted Available For Exclusive and Non-exclusive License
