Technical Description
The present invention provides a novel multifunctional molecule designed for the treatment of Alzheimer’s disease and other neurodegenerative diseases. The drug molecule is a 3-(4-hydroxy-3-methoxy-phenyl) prop-2-enoic acid derivative that is coupled with heterocyclic or substituted aromatic amines.
Problems Addressed
- Gradual Memory Loss
- Symptomatic Relief Drugs / Short Term Relief
- Limited Efficacy of Existing Treatments
- Limited AChE Interaction
- Poor Solubility & Blood Brain Barrier Penetration
- Environmentally Unsafe
- Toxic Aβ1-42 Aggregation
- Ferulic Acid (FA) with Low LogP
- Poor Yield & Purification with Chromatography
- Oxidative Stress
Tech Features
- Alleviate Symptoms & Reverse Neurodegeneration
- Combat FA Limitations
- High-Intensity Absorption at Neutral pH
- Improved AChE Inhibition in Low Micromolar Range with IC50
- High Yield without Chromatography Purification
- FA with Increased LogP
- Antioxidant Activity
- Inhibiting Mitochondrial Respiration
- Inhibition of Aβ1-42 Aggregation
- Improved Solubility and Blood Brain Barrier Penetration
Target Audience
- Pharmaceutical Industry
- Healthcare and Medical Sector
- Research and Development
Tech ID: 27-1150 TRL 4 Patent Status: Granted Available For Exclusive and Non-exclusive License
