Technical Description
This invention relates to a novel enantioselective domino carbopalladation/capture process using N-tosyl hydrazones as safe carbene precursors. It enables the single-step synthesis of chiral 3,3-disubstituted oxindoles, which are vital scaffolds in pharmaceutical and biological chemistry.
Problems Addressed
- Unstable Precursors Utility
- Harsh Reaction Conditions
- Limited Substrate Scope
- Inefficient Multi-Step Synthesis
- Enantioselective Variants Scarcity
- Lacks Intermediate Capture
Tech Features
- Enhanced Safety Protocols
- Efficient Single-Step Synthesis
- Broad Substrate Scope
- Refined Enantioselective Control
- Novel Carbene Capture
- Optimized Palladium Catalysis
Target Audience
- Specialty chemical industries
- Drug discovery laboratories
- Academic research institutions
- Contract Research Organizations (CROs)
- Research & Development
Tech ID: P27-1966 TRL 6 Patent Status: Granted Available For Exclusive and Non-exclusive License
