Technical Description
The technology discloses a green synthesis process for medicinally valuable multi-substituted 2-phenylimidazo-[1,2-a]pyridines using transition-metal-free regioselective C-H arylation. It uses visible light as a sustainable energy source and non-covalent interaction to obtain 2,3-diphenylimidazo[1,2-a]pyridine derivatives.
Problems Addressed
- Expensive Transition-Metal Catalysts
- Toxic Catalyst-Based Processes
- Prefunctionalized Starting Materials
- Limited Metal-Free C-H Arylation
- Aryl Halide Failure in Thermal Conditions
- Industrial-Scale Green Synthesis Need
Tech Features
- 2-Phenylimidazo[1,2-a]pyridine Substrate
- Halobenzene / Iodoarene Reactant
- KOtBu Base System
- Degassed DMSO Solvent
- 450 W Visible Light Source
Target Audience
- Pharmaceutical Industry
- Medicinal Chemistry Companies
- Chemical Manufacturers
- Academic & Industrial R&D Labs
Tech ID: P27-2023 TRL 3 Patent Status: Granted Available For Exclusive and Non-exclusive License
